Radiomics and radiogenomics for precision radiotherapy
نویسندگان
چکیده
منابع مشابه
Radiomics and radiogenomics for precision radiotherapy
Imaging plays an important role in the diagnosis and staging of cancer, as well as in radiation treatment planning and evaluation of therapeutic response. Recently, there has been significant interest in extracting quantitative information from clinical standard-of-care images, i.e. radiomics, in order to provide a more comprehensive characterization of image phenotypes of the tumor. A number o...
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Preclinical research using well characterized small animal models has provided tremendous benefits to medical research, enabling low cost, large scale trials with high statistical significance of observed effects. The goal of the Small Animal Radiation Research Platform (SARRP) is to make those models available for the development and evaluation of novel radiation therapies. SARRP demonstrates ...
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UNLABELLED Normal-tissue adverse effects following radiotherapy are common and significantly affect quality of life. These effects cannot be accounted for by dosimetric, treatment, or demographic factors alone, and evidence suggests that common genetic variants are associated with radiotherapy adverse effects. The field of radiogenomics has evolved to identify such genetic risk factors. Radioge...
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Recent whole-genome sequencing efforts have expanded on the traditional histologically-driven subtypes to further stratify cases according to the presence/absence of specific somatic mutations in oncogenes integral to cancer initiation, progression and metastasis. The development of ‘targeted therapeutics’ intended to specifically short-circuit regulatory pathways has led to the successful deve...
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ژورنال
عنوان ژورنال: Journal of Radiation Research
سال: 2018
ISSN: 0449-3060,1349-9157
DOI: 10.1093/jrr/rrx102